Endocrine Abstracts

Introduction: Dual energy X-ray absorptiometry (DXA) scans are regarded as the gold standard for assessing bone health. However, an inability to distinguish between cortical and trabecular bone as well as the use of inapproapriate size corrections mean that this technique is of limited clinical use in conditions affecting either bone microarchitecture or patient size. We have trialled the use of high resolution MRI (micro MRI) in the measurement of bone microarchitecture in pa...

Background: High-resolution magnetic resonance imaging (hrMRI) can assess trabecular bone microarchitecture but the number of image slices required for reliable assessment is unclear.Methods: MRI was performed just below the growth plate of the proximal tibia from 20 healthy controls (all females; median age 21 years (range 18.35) and ten cases (3M:7F; median age 19.5 years (range 16.48) with known bone abnormalities including osteogenesis imperfecta and...

Objective: The pathophysiology of the increased fracture risk in Type 1 Diabetes (T1D) remains unclear. Given that childhood and adolescence are important physiological periods for optimal bone development, we performed a multimodality assessment to determine the effects of T1D on bone health.Methods: Thirty two affected children at a median (range) age of 13.7 years (10.4, 16.7), were recruited for detailed assessment of bone health. Serum bone alkaline...